Business Intergration Essay Example for Free

Business Intergration Essay New IT developments are important to all business disciplines because they trigger changes in marketing operations, e-commerce, logistics, human resources, finance, accounting, and relationships with customers and business partners. Nothing about business or corporate strategy is untouched by IT (Turban Volonino, 2011). The five elements of an IT-enabled business strategy Business strategy| * Contains the mission, vision, and objectives of the organization * States the companys market strategy * Describes the unique value proposition the company offers customers * Provides the distinct value configuration of the organization| Business expectations of IT| * Describes how the company might expect IT to contribute to the success of the * business * Possible business expectations of IT include delivering better value, reducing costs, * or improving products and services| IT strategy| * Provides information on IT applications * Describes how to develop the competencies of the people who work in IT * States how IT is to be organized and controlled within the company * Describes the technical infrastructure| IT assessment| * Aims to reveal how technology helps or hinders a business * Can include network and systems performance reviews, software audits, and * concept testing and development * Can include strategic evaluations, technical reviews, and risk management * Should recommend how to use technology to meet business goals| IT plans| * Outlines a companys long-term IT plans * Is concerned with how IT should be deployed, managed, and implemented in the * future * Should be cost effective and in line with business goals| What are the advantages of aligning business and IT strategies? There are many advantages when an organization IT strategies are aligned with the organizations business strategies. Information technology is a key business function in almost every successful organization. An effective IT strategy will enable businesses to: * Reduce cost; * Standardize processes; * Enhance productivity; * Improve risk control mechanism; * Implement new business strategies; * Facilitate organic and acquisition driven growth; * Gain competitive advantage by exploiting new technology; Other benefits of the alignment of IT and business strategy is automation, knowledge, organizational improvements, and innovation. Automation can result in increased efficiency while decreasing cost. Knowledge in IT is the ability of an organization to collect, store, process, and disseminate information. The benefit of knowledge gained from IT is cost reduction, greater efficiency, and increased revenues. IT also leads to organizational improvements which usually lead to more decentralized leadership structure which improves the overall effectiveness of the organization. Proper alignment of IT and business strategy can make an organization stand out and look different from its competitors. This alignment can provide a competitive advantage for an organization. How does IT deliver business benefits that are related to the business strategy? IT delivers business benefit by performing high-speed, high volume, and numerical computation. IT provides fast, accurate communication and collaboration unrestricted by time and location. IT gives organizations the ability to store huge amounts of information that is accessible via private networks and the internet. In addition it enables automation of routine decisions making and help facilitate complex decision making. IT also improves the ability to make informed decisions. IT also helps to facilitate collaboration, enhance customer relationships, develop new analytic capabilities, and provide feedback on performance. Reference Turban, E., Volonino, L. (2011). Information Technology for Management (8th ed.). Hoboken, NJ: John Wiley Sons, Inc..

Graduation speech :: essays research papers

Hello and welcome†¦.. As a matter of formality I would like to introduce myself. My name is Bruce Richard and it gives me great pleasure to address you all today at Valencia High School. Thank you very much for this unique and rewarding opportunity. It is one I will never forget. I regard this as rewarding and memorable because I am being asked to recount my high school experiences and the impact they have had on me. This is particularly valuable in that I can retain this as a permanent record to look back and reflect upon in the future. As I look back in retrospect and ask myself if I always tried as hard as I could, I am left with the fact that maybe I didn’t put my entire effort into all my studies and take full advantage of the free education I was offered. As I recall, the subjects that most interested me, such as science and the hands on approach, tended to sustain my level of interest and motivation. On the other hand, subjects such as government and others were harder to stay focused on for some reason. I am certain that most students have the same experience. I guess some things just require us to buckle down a little more in order to really learn.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  (Brief Pause) I am truly proud of the fact that I shared in the successes of the school as I was part of the drama class for four years and helped us win 5th place amongst 60 schools for the â€Å"Taming of the Shrew†. I played varsity football in my senior year where we had a great 9-2 season. As I go on to Fullerton, I only wish I had stuck to my intentions of playing all four years, instead of being influenced by other people, particularly the opposite sex. I have learned that it is important to stick to your convictions if you feel as strongly about them as I did. When I was part of the cross country team in my sophomore and junior years I did quite well and always gave it my all, learning the value of struggling to achieve by discovering more about myself and my abilities. The part of me I never thought existed gave me the confidence to know that anything can be accomplished with the right determination and desire. I am committed to succeed and looking forward to playing football at Fu llerton. Graduation speech :: essays research papers Hello and welcome†¦.. As a matter of formality I would like to introduce myself. My name is Bruce Richard and it gives me great pleasure to address you all today at Valencia High School. Thank you very much for this unique and rewarding opportunity. It is one I will never forget. I regard this as rewarding and memorable because I am being asked to recount my high school experiences and the impact they have had on me. This is particularly valuable in that I can retain this as a permanent record to look back and reflect upon in the future. As I look back in retrospect and ask myself if I always tried as hard as I could, I am left with the fact that maybe I didn’t put my entire effort into all my studies and take full advantage of the free education I was offered. As I recall, the subjects that most interested me, such as science and the hands on approach, tended to sustain my level of interest and motivation. On the other hand, subjects such as government and others were harder to stay focused on for some reason. I am certain that most students have the same experience. I guess some things just require us to buckle down a little more in order to really learn.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  (Brief Pause) I am truly proud of the fact that I shared in the successes of the school as I was part of the drama class for four years and helped us win 5th place amongst 60 schools for the â€Å"Taming of the Shrew†. I played varsity football in my senior year where we had a great 9-2 season. As I go on to Fullerton, I only wish I had stuck to my intentions of playing all four years, instead of being influenced by other people, particularly the opposite sex. I have learned that it is important to stick to your convictions if you feel as strongly about them as I did. When I was part of the cross country team in my sophomore and junior years I did quite well and always gave it my all, learning the value of struggling to achieve by discovering more about myself and my abilities. The part of me I never thought existed gave me the confidence to know that anything can be accomplished with the right determination and desire. I am committed to succeed and looking forward to playing football at Fu llerton.

Studying chromosome 11 of the human genome

In this paper I will be studying chromosome 11 of the human genome. Specifically, I will be researching some of the diseases that occur when there are mutations in the genes on chromosome 11. Five specific diseases will be looked at and studied in detail: the Sickle Cell Anemia gene, the MLL gene which causes Trisomy 11, the H19 gene which causes Beckwith-Weideman Syndrome, the WT1 and PAX6 genes which causes Wilm's Tumor syndrome, and finally, the work being done on the genes of Chromosome 11q22-q24 regarding cervical carcinoma. The following research was all acquired from the NCBI online database. Read this Ch. 22 Respiratory System The HBB gene which causes Sickle Cell Anemia, is found on chromosome 11p15. 4. This gene causes an inherited blood disorder, mainly effecting people from the African continent (1/500), but also people from the Mediterranean and South Asian countries. (NCBI Online, 24 June 2003) Approximately 8% of the African American population are carriers; often, this gene is associated with malaria occurrence, as carriers are somewhat protected against malaria. (NCBI Online, 24 June 2003) Sickle cell anemia is an autosomal (not sex related) recessive disease caused by a mutation in the hemoglobin beta gene. When a mutation occurs, the HBB gene produces a structurally abnormal hemoglobin (Hb), called HbS. (NCBI Online, 24 June 2003) Hb is a protein which carries oxygen and gives red blood cells their distinctive color. In individuals who are homozygous for HbS, the abnormal HbS can bunch together, distorting the red blood cells into sickled shapes [as shown in Figure 1]. These clusters can only occur if the HbS is placed under certain circumstances or conditions, such as high hemoglobin concentrations or low oxygen levels. NCBI Online, 24 June 2003) When the mutated and rigid red blood cells become trapped within small blood vessels, they block the vessels causing pain and eventual damage to the organs in the body. (NCBI Online, 24 June 2003) Although a cure has not yet been found, medical advancements have allowed for the treatment of symptoms and complications associated with Sickle Cell Anermia. Hydroxyurea, an antitumor drug, has been used to induce the formation of fetal Hb (HbF), which is normally found in the fetus or newborn. When fetal Hb is present in persons with Sickle Cell Anemia, Hydrozyurea can prevent sickling from occuring. NCBI Online, 24 June 2003) The MLL gene which causes Trisomy 11 is located on chromosome 11q23. A mutation in this gene is a â€Å"very rare chromosomal disorder caused by a duplication (trisomy) of the end (distal) portion of the long arm of chromosome 11. † (Genetic Information and Patient Services, November 2003) This disorder is most often noticeable at birth; some characteristic features of the disorder are â€Å"delayed mental and physical development, retarded growth of the fetus during pregnancy and of the child after birth, an unusually small brain (microencephaly), and/or distinctive facial features. (Genetic Information and Patient Services, November 2003) The MLL gene can produce a type of leukemia which effects both sexes and mainly adults at an average age of 60. (Dessen & Huret, 2002) In general terms, trisomy refers to â€Å"the condition of having three copies of a given chromosome in each somatic cell rather than the normal number of two. † (Dictionary. com) The leukemia is specifically acute myeloid leukemia or AML. This syndrome is caused by only a partial tandem duplication of the MLL gene on chromosome 11. Dessen & Huret, 2002) A recent study has shown that â€Å"MLL tandem duplications are less common than previously reported. † (Schnittger, October 2003) Also, the MLL tandem duplications â€Å"are preferentially observed in AML with normal karyotypes, but can also be found in the presence of chromosome alterations. † (Schnittger, October 2003) Two scientists, Cheryl Shuman and Rosanna Weksberg studied the Beckwith-Wiedemann Syndrome, also referred to as BWS syndrome. The information for BWS syndrome is from their reports on their studies. Their studies show that â€Å"chromosome abnormalities involving 11p15 are found in 1% or less of cases. † (Shuman, 10 April 2003) This syndrome can occur with mutations of many different genes on chromosome 11: mutations in genes IGF2 and H195, 5-10% of sporadic cases and 40% of familial cases had mutations in the CDKNIC gene, 50% of cases had a loss of methylation at the KCNQIOT1 gene, and in 10-20% of patients, â€Å"paternal uniparental disomy for chromosome 11p15 [was] observed. † (Shuman, 10 April 2003) In diagnosing BWS, two major and one minor characteristic must be obvious out of a list of possible criteria. Some major criteria include: history of BWS in the family, macrosomia, abnormal earlobe pits or creases, an embryonal tumor in childhood, Hemihyperplasia (an asymmetric overgrowth of a area/areas of the body), and possibly a cleft palate. (Shuman, 10 April 2003) Some minor criteria include: premature birth, Neonatal hypoglycemia, advanced bone aging, and monozygotic twinning (usually in the females). (Shuman, 10 April 2003) If one parent has uniparental disomy (UPD), then prenatal testing is done to test for BWS syndrome in the fetus. Shuman, 10 April 2003) Beckwith-Wiedemann Syndrome is found in approximately 1 out of 13, 700 cases across the world. However, this number is probably slightly low as there are many milder cases that often go undiagnosed. In children born with BWS, there is a 20% mortality rate due to premature birth. Often, children born with BWS develop Wilms Tumor or other tumors. (Shuman, 10 April 2003) Dr. Alan Gandy summarizes Wilms tumor as an â€Å"embryonal renal neoplasm which is characterized usually by an abdominal mass. (Gandy, 1 March 1995) Wilms tumour is caused by the deletion of the gene WT2-1 on chromosome 11p13. Proper function of this gene is to encode a DNA-binding protein that is most often found in the fetal kidney â€Å"and in tissue that gives rise to the genitourinary system. † (Gandy, 1 March 1995) The DNA-binding protein is expected to be a â€Å"Kruppel-like zinc-finger protein. † (Gandy, 1 March 1995) However, the inactivation of WT2-1 causes the Wilms Figure 2: Wilms Tumor tumor. (Gandy, 1 March 1995) This tumor is prevalent in 1/12 000 live births and is the second most common extra cranial solid tumor in children. The tumor appears in the kidney soon after birth (6 months-10 years)[as shown in Figure 3] and is related to other cancers. (Gandy, 1 March 1995) Wilms tumor is frequently a symptom of other gene mutations, such as BWS and WAGR syndrome. (Gandy, 1 March 1995) Features of the Primary Wilms tumor include abdominal mass [as shown in Figure 2], abdominal pain, hypertension, and anemia etc. Metastases occurs in the lungs, lymph nodes, liver, brain and other areas to a lesser extent. (Gandy, 1 March 1995) Depending on the stage of the tumor, different actions can be taken to cure the tumor. Surgery (removal of the kidney and lymph nodes) and chemotherapy are both used as ways to manage the tumor. However, as the stages progress, likelihood of a cure is reduced. (Gandy, 1 March 1995) Studies done by G. M. Hampton et al. show that there are genes or a gene on chromosome 11 that has the ability to â€Å"[suppress] tumorigenicity in cell lines derived from different histopathological types of cervical carcinoma, suggesting that aberration of this gene(s) may represent at least one of the additional changes required for tumorigenic progression. ( Hampton, 19 July 1994) The suppressor gene specified is between 11q22 and q24. A study was performed on 32 patients with cervical carcinoma to conclude which genes were required for tumorigenic progression. â€Å"Of the 32 patients examined, 14(44%) demonstrated clonal genetic alterations resulting in loss of heterzygosity for one or more markers. Seven of the clonal genetic alterations on chromosome 11 were specific to the long arm, and the overlap between these and other allelic deletions suggest that a suppressor gene(s) relevant to cervical carcinoma maps to chromosome 11q22-q24. â€Å"( Hampton, 19 July 1994) In conclusion, Chromosome 11 of the Human genome contains over 1000 genes. Of the many, this essay looks at 5 specifically in order to gather information on the genes of this chromosome. Through the closes study of Sickle Cell Anemia, Trisomy 11, Beckwith-Weideman Syndrome, Wilm's Tumor syndrome, and the genes of Chromosome 11q22-q24 regarding cervical carcinoma, one can gather a better understanding of the genes on chromosome 11, and the type of mutations that occur. Although the Humane Genome Project is relatively new, there is already much information that has been revealed and still much more to be discovered.

The Scandal That Led to Milo Yiannopoulos Downfall

Breitbart editor and alt-right star Milo Yiannopoulos was poised to become a household name in the United States. Viewed as a bigot, Internet troll, and homophobe by his detractors—he’d likened feminism to cancer, told gays to â€Å"get back in the closet† and led a campaign of harassment against black actress Leslie Jones—the British transplant to the U.S. made headlines in early 2017 after his college tour sparked violence. When the University of California, Berkeley, canceled a Yiannopoulos speech because riots broke out on the campus in response, President Donald Trump took to Twitter to suggest that the university should lose federal funding for not supporting free speech. That the president would take the time to allude to him on social media signaled that Yiannopoulos, best known in right-wing circles, had successfully entered the mainstream. But less than a month later, the provocateur would lose his Simon Schuster book deal, his invitation to speak at CPAC, and his job at Breitbart. How did this dramatic turn of events come about? A review of Yiannopoulos’ life, career, and controversies reveal some of the factors that led to his rapid rise and shocking fall.    Early Years and Education Born Milo Hanrahan on Oct. 18, 1984, to a Greek-Irish father and an English mother, Yiannopoulos grew up in Kent in Southern England. Years later, he would change his surname to Yiannopoulos in honor of his Greek grandmother. Although he is now considered a darling of the alt-right movement, which has been linked to anti-Semitism, Yiannopoulos says that he has matrilineal Jewish ancestry. He grew up as a practicing Catholic, however, with his mother and stepfather. The openly-gay Yiannopoulos has indicated that he consented to have a sexual relationship with a Catholic priest, despite being underage at the time. This claim would factor into his downfall at the height of his career. By his teens, Yiannopoulos, who didn’t get along well with this mother’s husband, lived with his grandmother. Although he attended both the University of Manchester and Wolfson College, Cambridge, he never earned a degree, but his lack of education did not prevent him from having a journalism career in the United Kingdom. Journalism Career Yiannopoulos’ journalism career took off after he began working for the Daily Telegraph, where he developed an interest in tech journalism after reporting on women in computing in 2009. He also appeared in a number of broadcast news outlets and programs, including Sky News, â€Å"BBC Breakfast,† â€Å"Newsnight† and â€Å"10 O’Clock Live,† discussing topics such as feminism, men’s rights, the gay community and the Pope. Through this project  the Telegraph Tech Start-Up 100, he ranked influential European tech startups in 2011. That same year, he launched the Kernel, a tech journalism site. The online magazine became embroiled in scandal two years later after contributors to the publication sued for thousands of pounds of back pay. Yiannopoulos eventually paid six contributors the money owed to them. After changing ownership a couple of times, the Kernel was purchased by Daily Dot Media in 2014. Yiannopoulos served as an adviser but no longe r ​as editor. Political  Leanings Yiannopoulos has said he’s not interested in politics, but as his career progressed, he increasingly expressed views that aligned him with the alt-right, of which he’s described himself as a â€Å"fellow traveler.† He is said to have skewed coverage of 2014’s Gamergate controversy, which led to attacks, including death and rape threats, against prominent women gamers who’d criticized sexism in video game culture. Yiannopoulos described the women as â€Å"sociopathic,† despite the fact that they were the victims of relentless online attacks that forced them out of their homes when their addresses and other personal information were revealed on the Web through  a practice known as â€Å"doxxing.† In 2015, he organized a meeting of Gamergate supporters which received a bomb threat, as did a Society of Professional Journalists event featuring Yiannopoulos discussing Gamergate. Despite the outrage he sparked, Yiannopoulos’ notoriety earned him a position with Breitbart News Network, which named him  tech editor in 2015. The far-right news organization has been accused of reporting misinformation and fueling racism, anti-Semitism, and misogyny through its content. Former Breitbart News chair Stephen Bannon serves as an assistant and chief strategist for Donald Trump, whose election to the presidency has coincided with a rise of racial harassment  and white supremacist activity, including the killing of an Indian engineer and the desecration of Jewish cemeteries. Jewish magazine the Tablet has taken issue with Yiannopoulos for aligning himself with organizations that promote a racist, anti-Semitic or misogynistic agenda while maintaining that he doesn’t personally harbor such views. Tablet writer James Kirchick pointed out in 2016 that Yiannopoulos only mentions his matrilineal Jewish heritage when the anti-Semitism of his supporters comes to light. He said that Yiannopoulos’ Jewish heritage didn’t prevent him from wearing an Iron Cross medallion—a symbol of the Nazi regime — as a young man. Yiannopoulos has also defended himself against racism charges by saying that he prefers black men as lovers. â€Å"Like the insistence that he can’t be an anti-Semite because his mother has Jewish ancestors, Yiannopoulos’ assertion that his carnal desires inoculate him from the charge of bigotry is a deflection ploy,† Kirchick asserted. â€Å"Ironically, it’s also a form of the identity politics he claims to despise. While the ‘social justice warriors’ (SJWs) Yiannopoulos mocks say they cannot be racist or anti-Semitic on account of their identities, Yiannopoulos flimsily asserts the same about himself. The alt right should be absolved of similar imputations, Yiannopoulos says, because its spokesman is a gay half-Jew with jungle fever.† A Professional Troll The year 2016 saw Yiannopoulos’ star rise exponentially. That’s in large part because he kicked off his â€Å"Dangerous F----t† college tour in late 2015, which led to protests nationwide at universities such as Rutgers, DePaul, the University of Minnesota, the University of Pittsburgh and the University of California, Los Angeles. During this timeframe, Yiannopoulos began to earn a reputation for being a professional troll. Twitter, for example, suspended his account in December 2015 after he indicated on his profile that he was BuzzFeed’s social justice editor (which he was not). Twitter suspended his account once again after he made anti-Muslim remarks following the June 2016 mass shooting at Pulse, a gay nightclub in Orlando, Fla. Yiannopoulos was permanently banned from the social media site in July for inciting a campaign of racial harassment against black actress Leslie Jones, a star of the all-female â€Å"Ghostbusters† remake. He compared Jones to a man, and his fans likened her to apes, a comparison white supremacists have long used to dehumanize blacks. Yiannopoulos denied culpability for the racist abuse Jones received but was still banned from Twitter, as hed also crafted fake tweets photoshopped to look as if theyd been sent from her account. He later said that he was thankful for the ban for giving him more notoriety. The idea that Yiannopoulos is simply a troll using politics to become famous spread when BuzzFeed quoted a  Breitbart intern saying â€Å"Milo Yiannopoulos is not one person.† Reportedly, 44 interns are responsible for crafting his articles and social media posts. Yiannopoulos seemed to admit as much at first, saying that was the norm for someone with a career like his. But he later backtracked, implying that he didn’t rely on ghostwriters. Whatever the case, critics such as Kirchick contend that Yiannopoulos is a â€Å"rank opportunist.†   He shouts â€Å"outrageous things solely designed to upset liberals. He has nothing original or interesting to share,† Kirchick asserts. Because he makes his points in a â€Å"crude† fashion, however, Yiannopoulos manages to court controversy and stay in the news. In December 2016, Yiannopoulos made headlines after news spread that publishing giant Simon Schuster had just given him a book deal with a $250,000 advance. The announcement not only prompted the Chicago Review of Books to stop reviewing Simon Schuster books but also black feminist writer Roxane Gay to walk away from her book deal with the publisher. Pride Before the Fall At the onset of 2017, arguably more Americans than ever had become familiar with Milo Yiannopoulos. On Jan. 20, the same day as Trump’s inauguration, Yiannopoulos spoke at the University of Washington. Violent demonstrations took place outside, with a Yiannopoulos supporter shooting a protester at the event. The gunshot resulted in life-threatening injuries, but the victim survived.    On Feb. 1, Yiannopoulos was scheduled to speak at UC Berkeley. An estimated 1,500 protesters gathered outside. Some started fires, engaged in vandalism and pepper sprayed passersby, leading the campus police to cancel his appearance. This provoked Donald Trump to tweet about defunding the University of California for not upholding free speech. The outcry over Yiannopoulos’ college tour didn’t deter comedian Bill Maher from inviting the journalist on his â€Å"Real Time† show on Feb. 17, however. And the very next day, Matt Schlapp, chairman of the American Conservative Union, announced that Yiannopoulos had been invited to speak to the Conservative Political Action Committee (CPAC). The invitation sparked some conservatives to speak out in opposition, but CPAC stood firm. Then, a conservative blog called the Reagan Battalion tweeted a video from 2015  of Yiannopoulos saying he consented to have a sexual relationship with a priest when he was a teen. It went on to tweet out other videos of Yiannopoulos defending underage males having sex with adults. In the clip that sparked the most controversy, Yiannopoulos said: â€Å"Some of those relationships between younger boys and older men, the sort of coming-of-age relationships, the relationships in which those older men help those young boys to discover who they are, and give them security and safety and provide them with love and a reliable and sort of a rock where they can’t speak to their parents.† Yiannopoulos also made a snarky remark about the priest who allegedly abused him. â€Å"I’m grateful for Father Michael,† he said. â€Å"I wouldn’t give nearly such good [oral sex] if it wasn’t for him.† He also made a point to say that sex with young teens did not constitute pedophilia, as sex with children did. Due to these remarks, Yiannopoulos was widely accused of advocating for adults to have sex with underage teens. The backlash was swift. CPAC disinvited him from its conference. Simon Schuster canceled his book deal, and Yiannopoulos resigned from Breitbart after staffers said they would quit if he wasn’t fired. Yiannopoulos expressed regret for his choice of words, but it wasn’t enough to convince his former allies to stand behind him. â€Å"I’ve repeatedly expressed disgust at pedophilia in my feature and opinion writing,† he said in a Facebook statement on Feb. 20. â€Å"My professional record is very clear. But I do understand that these videos, even though some of them are edited deceptively, paint a different picture. I’m partly to blame. My own experiences as a victim led me to believe I could say anything I wanted to on this subject, no matter how outrageous. But I understand that my usual blend of British sarcasm, provocation and gallows humor might have come across as flippancy, a lack of care for other victims or, worse, ‘advocacy.’ I deeply regret that. People deal with things from their past in different ways.† Now that Yiannopoulos’ career at Breitbart is in the past, members of the groups he offended—women, Jews, blacks, gays—question why only  his remarks about the age of consent led his supporters to disavow him. Why didn’t it concern CPAC, Simon Schuster et al. that Yiannopoulos had made odious remarks about women’s rights, gay rights or civil rights generally? They argue the idea that only his tacit endorsement of pedophilia made Yiannopoulos unfit for the large platform he was given sets a low bar for civil discourse and  overlooks the impact of bigotry  on the marginalized.